Sequence design

Choosing a sequence’s parameters by minimizing a cost you write. The acquisition is a simulator with the tissue it is designed for already fixed on it; the cost is a plain function of what it records; a SequenceDesign holds the parameters and runs the loop.

Bounded holds a parameter inside the limits the scanner will play, by optimizing a transformed variable – no iterate is ever outside them. crlb() turns the derivative of a signal with respect to tissue into the lowest variance an unbiased estimate of it can have, which is the cost a precision-driven design minimizes.

Bounded	An initial value and the range it is allowed to move in.
SequenceDesign	A cost, the parameters it is minimized over, and the limits on them.
crlb	The lowest variance an unbiased estimate of each parameter can have.